Common Characteristics of Alzheimer’s Disease

Mnemonic: “ALZHEIMER’S”

A: Anterograde amnesia is usually first sign
L: Life expectancy increase shows more cases in recent years
Z: Zapped (loss of) acetylcholinergic neurons
H: Hereditary disease
E: Entire hippocampus becomes affected
I: Identified by neurofibrillary tangles
M: Mutation in amyloid genes associated w/ disease
E: Entorhinal areas degenerate first
R: Retrograde amnesia ultimaltely develops
S: Senile plaques are formed at synapse

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