Sweet Syndrome

Sweet syndrome is a very rare inflammatory skin condition characterized by a sudden onset of fever and painful rash on the arms, legs, trunk, face, or neck. It’s also known as acute febrile neutrophilic dermatosis.

Reddish-blue/violet papules, plaques, or nodules with massive subepidermal edema which can form bullae and ulcerate. Mucosal involvement also fits.

Screen for underlying (hematologic) malignancy and rule out infection. CBC, CRP/ESR, LFT, ANCA, urinanalysis, biopsy. Sweet’s syndrome typically responds to prednisone rapidly.

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